A high-dimensional cytometry atlas of peripheral blood over the human life span

S Jalali; CM Harpur; AT Piers; M Auladell; L Perriman; S Li; K An; J Anderson; SP Berzins; PV Licciardi; TM Ashhurst; IE Konstantinov; DG Pellicci

Journal article

A high-dimensional cytometry atlas of peripheral blood over the human life span

S Jalali, CM Harpur, AT Piers, M Auladell, L Perriman, S Li, K An, J Anderson, SP Berzins, PV Licciardi, TM Ashhurst, IE Konstantinov, DG Pellicci

Immunology and Cell Biology | Published : 2022

DOI: 10.1111/imcb.12594

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Abstract

Age can profoundly affect susceptibility to a broad range of human diseases. Children are more susceptible to some infectious diseases such as diphtheria and pertussis, while in others, such as coronavirus disease 2019 and hepatitis A, they are more protected compared with adults. One explanation is that the composition of the immune system is a major contributing factor to disease susceptibility and severity. While most studies of the human immune system have focused on adults, how the immune system changes after birth remains poorly understood. Here, using high-dimensional spectral flow cytometry and computational methods for data integration, we analyzed more than 50 populations of immune..

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University of Melbourne Researchers

Sedi Jalali Author

Jeremy Anderson Author

Stuart Berzins Author

Paul Licciardi Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

We acknowledge Elena Batleska and Scott Reddiex for technical input and Eleanor Jones and Matthew Burton for flow cytometry. SJ is supported by a Melbourne Research Scholarship, DGP is supported by CSL Centenary Fellowship, SPB is supported by a Dorevitch Cancer Research Fellowship, PVL is supported by an NHMRC Career Development Fellowship (1146198) and JA is supported by an Australian Postgraduate Award. This research is supported by NHMRC grants 1145373, 1140126 and 1122890 and Heart Foundation Vanguard Grant 102236. Open access publishing facilitated by The University of Melbourne, as part of the Wiley -The University of Melbourne agreement via the Council of Australian University Librarians.